Abstract
Effects of drug-state changes upon starting and running responses in a straight runway in shock-motivated rats
S. Iwahara & T. Takahashi
Rats were run 20 trials per day for 10 days, in the straight runway, shock being administered from the floor if they failed to enter the safe goal box within 5 sec. Half the rats were given either saline or 20 mg/kg, i.p, of CDP, 30 min prior to daily trials for Days 1 to 4. (L1), half of each group were shifted their drug state from L1 to L2 (Days 5 to 7), and finally half of the rats in each subgroup were shifted their drug state from L2 to L3 (Days 8-10). Both starting time (ST) and running time (RT) were increased by CDP and only ST was state-dependent. In addition, ST tended to decrease if drug state was shifted in L3 back to the original state in L1. The facts that only ST showed ordinary learning curves and it was not correlated with RT, suggested that only those responses which are shown to be conditionable may be state-dependent.