Eighty-four patients suffering from depression were compared with 84 matched normal controls with respect to various GSR characteristics. Non-significant group difference was obtained with respect to all the GSR characteristics except amplitude. Later a symptomatic categorization of the patients was made in order to see whether the patients could be more distinctly differentiated from the normals on the basis of the response characteristics, and whether the patients having similar symptoms would show any similarity amongst themselves in their response characteristics. Symptomatic categorization was found fruitful. All the three sub-categories i.e., agitated, retarded and uncomplicated depressives differed significantly amongst themselves as well as from the normals with respect to most of the GSR characteristics.